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Biotin Research Marginal biotin deficiency during normal pregnancy. A case of partial biotinidase deficiency associated with autism. Biotin deficiency stimulates survival pathways in human lymphoma cells exposed to antineoplastic drugs. Pharmacological effects of biotin. Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts. Biotin deficiency affects the proliferation of human embryonic palatal mesenchymal cells in culture. Biotin supplementation increases expression of genes encoding interferon-gamma, interleukin-1beta, and 3-methylcrotonyl-CoA carboxylase, and decreases expression of the gene encoding interleukin-4 in human peripheral blood mononuclear cells.



  

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